Table 2.
IVF outcome of patients subdivided in the three groups of expected poor responders (ePR), expected normal responders (eNR), and expected high responders (eHR). Monitoring checkpoints (E2 + US) were significantly fewer in the eNR group with day 4 regimen (*p < 0.05). The “freeze-all” strategy, applied to lower the OHSS risk in the eHR group, was significantly more frequent with day 2 regimen (*p < 0.05). No significant differences between patients receiving CFα day 2 or CFα day 4 regimen were observed for all other variables considering all patients together as well as those in subgroups eHR and eNR. In the ePR subgroup, the clinical pregnancy rate per started cycle and per ET, as well as the cumulative live birth rate per OPU, were significantly higher for CFα day 2 regimen (**p < 0.04)
| ePR | eNR | eHR | All patients | |||||
|---|---|---|---|---|---|---|---|---|
| CFα day 2 (n = 16) | CFα day 4 (n = 15) | CFα day 2 (n = 20) | CFα day 4 (n = 19) | CFα day 2 (n = 21) | CFα day 4 (n = 22) | CFα day 2 (n = 57) | CFα day 4 (n = 56) | |
| Total rFSH added (IU) | 840 ± 546 | 600 ± 543 | 660 ± 361 | 473 ± 334 | 314 ± 205 | 293 ± 206 | 1871 ± 487 | 1736 ± 462 |
| Days of GnRH antag | 4.7 ± 2.2 | 4.5 ± 2.1 | 5.9 ± 1.9 | 4.7 ± 1.9 | 5.7 ± 2.0* | 5.5 ± 1.8 | 5.5 ± 2.0 | 4.8 ± 1.9 |
| Monitoring checkpoints | 2.6 ± 0.97 | 2.8 ± 0.8 | 3 ± 0.7 | 2.3 ± 0.7* | 2.8 ± 0.8 | 2.8 ± 0.7 | 2.8 ± 0.8 | 2.7 ± 0.7 |
| E2 at trigger (pg/ml) | 515 ± 294 | 858 ± 820 | 1493 ± 1107 | 1197 ± 568 | 1564 ± 881 | 1782 ± 999 | 1244 ± 963 | 1336 ± 898 |
| Pg at trigger (ng/ml) | 0.5 ± 0.5 | 0.5 ± 0.2 | 0.5 ± 0.3 | 0.6 ± 0.7 | 0.9 ± 0.3 | 0.8 ± 0.3 | 0.5 ± 0.4 | 0.6 ± 0.4 |
| Cancellation rate (%) | 18 (3/16) | 40 (6/15) | 5 (1/20) | 5 (1/19) | 0 (0/21) | 4 (1/22) | 7.0 (4/57) | 14.3 (8/56) |
| Freeze all (high OHSS risk) (%) | 0/16 | 0/15 | 0/20 | 0/19 | 38 (8/21)* | 9 (2/22) | 14 (8/57) | 3.6 (2/56) |
| Retrieved oocytes/OPU | 4.3 ± 3.3 | 4.2 ± 2.9 | 7.3 ± 5.2 | 6.7 ± 4.0 | 12.8 ± 6.1 | 12.8 ± 5.1 | 8.8 ± 6.2 | 8.9 ± 5.6 |
| MII oocytes/OPU | 3.6 ± 3.0 | 3.1 ± 2.6 | 6.0 ± 3.7 | 5.1 ± 3.3 | 10.1 ± 4.7 | 10.3 ± 4.4 | 7.1 ± 4.8 | 7.0 ± 4.7 |
| Fertilization Rate (%) | 59.7 ± 29.1 | 65.1 ± 32.9 | 72.9 ± 28.5 | 65.4 ± 31.3 | 71.1 ± 28.1 | 70.1 ± 26.4 | 69.4 ± 28.3 | 67.5 ± 28.9 |
| Transferred embryos | 1.2 ± 0.8 | 1 ± 0.6 | 1.5 ± 0.8 | 1.4 ± 0.8 | 1.6 ± 1 | 1.6 ± 0.9 | 1.5 ± 1 | 1.5 ± 0.9 |
| Mean embryo score | 6.2 ± 2.9 | 5.3 ± 3.1 | 7.2 ± 2.5 | 7 ± 2.8 | 8.8 ± 3.1 | 8.4 ± 3.7 | 7.9 ± 3.5 | 7.5 ± 3.9 |
| Clinical PR/SC (%) | 18.7 (3/16)** | 0 (0/15) | 25 (5/20) | 15.8 (3/19) | 47.6 (10/21) | 50.0 (11/22) | 31.6 (18/57) | 25 (14/56) |
| Clinical PR/fresh ET (%) | 27.2 (3/11)** | 0 (0/6) | 26.3 (5/19) | 16.7 (3/18) | 69.2 (9/13) | 57.9 (11/19) | 39.5 (17/43) | 31.1 (14/45) |
| Cumulative LBR/OPU (%) | 23.1 (3/13)** | 0 (0/9) | 26.3 (5/19) | 16.7 (3/18) | 57.1 (12/21) | 52.4 (11/21) | 37.7 (20/53) | 29.2 (14/48) |