Table 1.

The effect of various doses of metformin on body weight, organ weight, blood glucose, and hormone level in Swiss albino mice

Metformin dose (mg/kg)	Body weight gain (g) (n = 36)	Blood glucose (mg/dL) (n = 8)	Ovary weight (mg) (n = 32)	Spleen weight (mg) (n = 6)	Liver weight (g) (n = 6)	Liver/spleen ratio	Estradiol (pg/mL) (n = 5)	Testosterone (ng/mL) (n = 5)
0	2.59 ± 0.24	122.63 ± 7.81	9.54 ± 0.54	188.53 ± 18.70	1.31 ± 0.72	6.96	19.51 ± 3.52	0.34 ± 0.05
50	2.63 ± 0.37	120.25 ± 4.31	10.16 ± 0.59	154.15 ± 15.30	1.11 ± 0.59	7.18	18.85 ± 2.56	0.25 ± 0.03
100	2.39 ± 0.27	119.63 ± 6.58	10.10 ± 0.63	140.52 ± 19.25	1.12 ± 0.45	8.02	16.06 ± 3.11	0.22 ± 0.04
200	2.83 ± 0.37	131.88 ± 5.49	9.36 ± 0.30	105.98 ± 8.76a	1.26 ± 0.47	11.98	17.34 ± 3.65	0.20 ± 0.02

Data were expressed as mean ± SE. ^aP < 0.05 compared with the control group