Table 5.

Effect of various doses of metformin on the reproductive potential of female mice and the post-natal development in progenies

Metformin (mg/kg)	Mating efficiency (%)	Total number of litters	Average litter size	Body weight of progenies (g)
				Parturition	2 weeks	4 weeks	8 weeks
0	86	93	8.50 ± 0.40	1.49 ± 0.01	5.92 ± 0.11	13.21 ± 0.30	23.60 ± 0.40
50	71	85	8.50 ± 0.45	1.43 ± 0.02	6.24 ± 0.09	14.67 ± 0.31a	24.15 ± 0.43
100	86	99	9.00 ± 0.41	1.43 ± 0.01a	6.23 ± 0.11	13.63 ± 0.31	24.81 ± 0.40
200	100	93	8.38 ± 0.43	1.46 ± 0.02	6.38 ± 0.11b	11.75 ± 0.41a,c,d	25.08 ± 0.47

The data were expressed as mean ± SE [n = 12 females and 12 males (1:1 ratio)] for all parameter except for mating efficiency which is expressed in percentage

^aP < 0.05, ^bP < 0.01 compared with control; ^cP < 0.001 compared with 50 mg/kg; ^dP < 0.001 compared with 100 mg/kg