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. 2020 May 22;10:8587. doi: 10.1038/s41598-020-65468-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The IC₅₀ concentration of the Cur_NE following ultrasound exposure at intensity 0.9, 1.5 and 2 W/cm² in (A) MDA MB 231 cells, **P ≤ 0.01, ***P ≤ 0.001 (C) B16F10 cells, ***P ≤ 0.001. The IC₅₀ concentration of the Cur_NE at ultrasound intensity 2 W/cm² in presence of 0.2 and 0.3 mg of MB in: (B) MDA MB 231, ***P ≤ 0.001 (D) B16F10 cells, *P ≤ 0.05, **P ≤ 0.01. Data are presented in the form of mean ± SD and P value was determined by Student t-test.