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. 2020 May 22;10:8587. doi: 10.1038/s41598-020-65468-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic presentation of the mechanism of absorption of the Cur_NE in the stomach and small intestine. The figure also shows the aggregation of Cur_NE in the stomach and intestinal absorption of the same in either free form or inside chylomicrons. II. (A) The concentration of curcumin in plasma following oral and intravenous administration of formulations. (B) Biodistribution of curcumin in vital organs after oral and intravenous administration of formulations. Cur (I.V.) and Cur (Oral) stands for intravenous and oral administration of free curcumin.