Table 2.
List of 53 4-HNE-bound proteins in cardiomyocytes of MAO-A Tg mice compared with WT mice (cutoff ratio > 2 and p value < 0.05).
| Proteins | MW (kDa) | Fold change | t-test |
|---|---|---|---|
| Astn2 | 99.9 | 15.6 | 4.96E−05 |
| COX2 | 26.0 | 4.9 | 4.20E−05 |
| Ces1d | 61.8 | 4.6 | 1.10E−03 |
| Myh11 | 223.4 | 4.5 | 1.05E−02 |
| Bcam | 21.1 | 4.4 | 2.59E−03 |
| Col6a4 | 250.8 | 4.2 | 1.04E−02 |
| Tmx1 | 14.3 | 3.6 | 3.52E−02 |
| Hk1 | 108.3 | 3.2 | 9.82E−04 |
| Macrod1 | 35.3 | 3.1 | 6.89E−05 |
| COX3 | 29.9 | 3.1 | 7.27E−04 |
| Sdha | 72.6 | 3.0 | 8.69E−08 |
| Cox4i1 | 19.5 | 2.9 | 3.56E−05 |
| Actn2 | 103.9 | 2.9 | 9.13E−05 |
| Uqcrc1 | 52.8 | 2.8 | 4.60E−05 |
| Bsg | 24.1 | 2.8 | 6.66E−04 |
| Mybpc3 | 141.3 | 2.7 | 7.28E−04 |
| Vdac2 | 30.4 | 2.7 | 6.58E−04 |
| Uqcrc2 | 48.2 | 2.7 | 2.90E−05 |
| Hibadh | 35.5 | 2.6 | 6.87E−04 |
| Cox6c | 8.5 | 2.6 | 6.92E−03 |
| Glud1 | 61.3 | 2.5 | 1.43E−02 |
| Trim21 | 53.2 | 2.5 | 3.13E−02 |
| Atp1b1 | 35.2 | 2.5 | 2.72E−03 |
| Sdhb | 27.2 | 2.5 | 2.45E−05 |
| Ndufs2 | 52.6 | 2.4 | 4.56E−04 |
| Uqcrfs1 | 29.4 | 2.4 | 9.50E−04 |
| Ndufs1 | 79.7 | 2.4 | 7.22E−05 |
| Akr1b10 | 32.7 | 2.4 | 2.24E−02 |
| Ndufa10 | 40.6 | 2.3 | 8.03E−04 |
| Mdh2 | 35.6 | 2.3 | 2.64E−06 |
| Ndufs7 | 24.7 | 2.3 | 1.79E−02 |
| Coq9 | 27.9 | 2.2 | 9.89E−04 |
| Ugp2 | 55.5 | 2.2 | 9.17E−05 |
| Vdac1 | 30.7 | 2.2 | 1.37E−04 |
| Ndufa8 | 20.0 | 2.2 | 4.44E−02 |
| Bdh1 | 38.3 | 2.1 | 4.43E−05 |
| Try4 | 26.3 | 2.1 | 4.42E−04 |
| Ldha | 34.5 | 2.1 | 7.77E−05 |
| Etfdh | 61.2 | 2.1 | 3.99E−04 |
| Hibch | 43.0 | 2.1 | 4.99E−04 |
| Kdm2b | 144.9 | 2.1 | 1.60E−02 |
| Atp1a1 | 113.0 | 2.1 | 2.36E−03 |
| Sirt5 | 34.1 | 2.1 | 2.98E−03 |
| Slc16a1 | 38.2 | 2.1 | 6.76E−05 |
| Ndufa12 | 17.4 | 2.1 | 1.98E−04 |
| Akr7a2 | 40.6 | 2.1 | 3.21E−03 |
| Mdh1 | 36.5 | 2.0 | 1.02E−04 |
| Reep5 | 21.1 | 2.0 | 3.34E−04 |
| Atp2a2 | 109.8 | 2.0 | 4.65E−02 |
| Got2 | 47.4 | 2.0 | 8.99E−07 |
| Aldoa | 39.3 | 2.0 | 1.29E−05 |
| Aldh4a1 | 61.8 | 2.0 | 2.96E−04 |
| Aco2 | 85.5 | 2.0 | 4.66E−06 |