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. 2019 Dec 5;27(6):1782–1794. doi: 10.1038/s41418-019-0461-z

Fig. 6. DANCR overexpression promotes, whereas DANCR KO suppresses tumor progression.

Fig. 6

a DANCR promotes the tumor growth of BXPC-3 cells. DANCR overexpression (DANCR) and vector control (pCDH-MSCV-copGFP-T2A-Pu) cells were subcutaneously injected into the nude mice with 1 × 104, 1 × 105, 5 × 105 cells per mouse as indicated in “Materials and methods”. b DANCR KO significantly suppresses the tumor growth rate of BXPC-3 cells. DANCR KO and vector control (pY108) cells were subcutaneously injected into the nude mice with 1 × 104, 1 × 105, 5 × 105 cells per mouse as in (a). (c) DANCR KO inhibits tumorigenesis of BXPC-3 cells in orthotopic pancreatic tumor mouse model. DANCR KO and vector control cells were injected into the pancreas of nude mice with 1 × 106 cells per mouse as detailed in “Materials and methods”. Values in a, b are mean ± SEM. P < 0.05; **P < 0.01.