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. 2020 May 22;10:8558. doi: 10.1038/s41598-020-65353-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HE4 regulates immune-related gene expression in peripheral blood mononuclear cells (A,B) Scatter plots of gene expression determined by quantitative PCR array in control or rHE4-treated PBMC. qPCR was performed to validate genes changes, revealing upregulation of CSF3, IL8, and HIF1A with rHE4 treatment of PBMC (C–E). No change in STAT3 or VEGFA levels were observed with rHE4 treatment (F,G). Error bars represent standard deviation. *p < 0.05. Results are the average of at least three biological replicates.