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. 2020 May 22;10:8558. doi: 10.1038/s41598-020-65353-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HE4-mediated tube formation of endothelial cells is blocked by STAT3 inhibition (A) rHE4 promotes tube formation of HUVECs, and STAT3 inhibition blocks tube formation in rHE4-treated cells. Top panel shows representative 4x images with tube features outlined in blue and tube numbers labeled. Bottom panel shows representative 10x images. (B) Quantification of tube formation from (A). Error bars represent standard deviation of at least three biological replicates. *p < 0.05, **p < 0.005.