Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
hyperSMURF and parSMURF (with grid search and Bayesian optimization) prediction performance obtained over a fully independent Mendelian test set composed of newly annotated pathogenic variants (positive examples) and common neutral variants (negative examples)
| Model | AUROC | AUPRC |
|---|---|---|
| hyperSMURF | 0.945216 | 0.098153 |
| parSMURF, grid search | 0.941026 | 0.409067 |
| parSMURF, Bayesian optimizaion | 0.928158 | 0.192568 |
