Table 2.

Primary and secondary endpoints

Primary endpoints

• A composite of all-cause mortality and hospitalization for recurrent non-fatal myocardial infarction, unstable angina pectoris, stroke, or acute decompensated heart failure

Secondary endpoints

• Each of the components of the primary outcome

• Cardiovascular mortality

• Atrial fibrillation and atrial flutter

• Cardiac arrest

• Ventricular arrhythmias

• Stable angina pectoris

• Bradycardia, syncope, or need for pacemaker

• Hospitalization for asthma and chronic obstructive pulmonary disorder

• Hospitalization for diabetes (new onset and dysregulation)

• Hospitalization for dysregulated blood pressure

• Peripheral artery disease

• Blood pressure controla

• Exercise capacitya

Patient reported outcomes (PRO) regarding:

• Health-related quality of life, depression, sexual dysfunction, angina burden following MI, and sleep disorders

^aAvailable for patients attending cardiac rehabilitation