Fig. 1.

Glucose-stimulated insulin secretion in control islets and in islets exposed to trivalent arsenicals. Isolated pancreatic islets were exposed to arsenicals for 48 h and stimulated with 2.5 mM glucose for 1 h followed by 16.7 mM glucose for 1 h. Islets incubated in Asfree medium for 48 h were used as controls. Insulin secretion (a) and cell viability measured via MTT assay (b) are shown as mean + SEM for N = 5 biological replicates (assay done in triplicate with 15 islets per replicate). *p < 0.05, the amount of insulin secreted by As-treated islets is significantly different from that secreted by control islets