Supplementary Table 2.
Univariable Cox regression for analyzing the prognostic factors for gastric cancer patients with distant metastases.
| Subject characteristics | M-Met | Liver-Met | Lung-Met | Bone-Met | Brain-Met | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age | ||||||||||
| <65 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| ≥65 | 1.31 (1.26–1.36) | <0.001 | 1.34 (1.26–1.42) | <0.001 | 1.17 (1.06–1.29) | 0.001 | 1.12 (1.01–1.24) | 0.036 | 1.14 (0.87–1.49) | 0.355 |
| Gender | ||||||||||
| Male | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| Female | 0.98 (0.94–1.02) | 0.333 | 0.95 (0.89–1.01) | 0.116 | 1.02 (0.92–1.13) | 0.702 | 1.04 (0.94–1.17) | 0.442 | 1.02 (0.75–1.38) | 0.894 |
| Race | ||||||||||
| White | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| Black | 0.99 (0.93–1.04) | 0.597 | 0.95 (0.88–1.02) | 0.166 | 1.12 (0.97–1.30) | 0.135 | 1.16 (0.98–1.37) | 0.084 | 1.16 (0.72–1.87) | 0.540 |
| Others | 0.99 (0.94–1.05) | 0.746 | 0.99 (0.91–1.09) | 0.850 | 1.14 (0.98–1.32) | 0.950 | 1.06 (0.91–1.24) | 0.460 | 1.29 (0.81–2.05) | 0.290 |
| Marital status | ||||||||||
| Married | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| Unmarried | 1.18 (1.13–1.23) | <0.001 | 1.15 (1.09–1.22) | <0.001 | 1.21 (1.10–1.34) | <0.001 | 1.13 (1.02–1.26) | 0.025 | 1.03 (0.78–1.38) | 0.825 |
| Insurance status | ||||||||||
| Insured | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| Uninsured | 1.05 (0.96–1.14) | 0.303 | 1.14 (0.99–1.30) | 0.067 | 1.07 (0.85–1.35) | 0.562 | 1.08 (0.84–1.38) | 0.548 | 1.54 (0.86–2.78) | 0.148 |
| Primary site | ||||||||||
| Proximal third | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| Mid | 1.06 (0.99–1.14) | 0.084 | 1.04 (0.93–1.15) | 0.495 | 1.18 (0.97–1.43) | 0.100 | 1.29 (1.08–1.55) | 0.006 | 1.69 (0.89–3.23) | 0.112 |
| Distal third | 1.02 (0.97–1.08) | 0.488 | 1.04 (0.96–1.14) | 0.328 | 1.18 (1.01–1.38) | 0.043 | 1.32 (1.10–1.57) | 0.002 | 1.43 (0.81–2.54) | 0.222 |
| Stomach, NOS | 1.06 (1.01–1.11) | 0.017 | 1.00 (0.93–1.07) | 0.983 | 1.19 (1.06–1.34) | 0.003 | 1.18 (1.04–1.33) | 0.010 | 1.44 (1.06–1.96) | 0.021 |
| Overlapping | 1.17 (1.09–1.26) | <0.001 | 1.29 (1.15–1.44) | <0.001 | 1.32 (1.08–1.60) | 0.006 | 1.17 (0.95–1.46) | 0.147 | 0.97 (0.40–2.37) | 0.944 |
| Histology | ||||||||||
| Adenoca-rcinoma | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| Mucous carcinoma | 1.02 (0.88–1.17) | 0.845 | 1.43 (1.11–1.85) | 0.005 | 1.00 (0.70–1.42) | 0.995 | 0.73 (0.47–1.14) | 0.163 | 0.95 (0.24–3.85) | 0.944 |
| Signet-ring cell carcinoma | 1.06 (1.01–1.11) | 0.018 | 1.17 (1.04–1.31) | 0.007 | 1.13 (0.99–1.30) | 0.080 | 1.01 (0.90–1.14) | 0.831 | 1.35 (0.95–1.92) | 0.099 |
| Unknown | 0.67 (0.63–0.71) | <0.001 | 0.63 (0.58–0.69) | <0.001 | 1.07 (0.92–1.26) | 0.372 | 1.07 (0.88–1.29) | 0.502 | 1.11 (0.70–1.77) | 0.665 |
| Grade | ||||||||||
| I | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| II | 1.51 (1.30–1.77) | <0.001 | 1.57 (1.28–1.92) | <0.001 | 1.24 (0.89–1.73) | 0.204 | 0.74 (0.44–1.24) | 0.251 | NA | NA |
| III | 1.83 (1.57–2.12) | <0.001 | 2.02 (1.66–2.47) | <0.001 | 1.65 (1.20–2.28) | 0.002 | 0.95 (0.58–1.55) | 0.825 | NA | NA |
| IV | 1.34 (1.09–1.65) | 0.005 | 1.46 (1.11–1.92) | 0.008 | 1.12 (0.65–0.94) | 0.691 | 0.88 (0.46–1.70) | 0.700 | NA | NA |
| T stage | ||||||||||
| T1 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| T2 | 0.71 (0.64–0.78) | <0.001 | 0.59 (0.50–0.70) | <0.001 | 0.90 (0.68–1.20) | 0.456 | 0.58 (0.43–0.80) | 0.001 | 1.30 (0.62–2.72) | 0.486 |
| T3 | 0.71 (0.66–0.76) | <0.001 | 0.68 (0.61–0.75) | <0.001 | 0.90 (0.75–1.07) | 0.225 | 0.83 (0.69–1.01) | 0.059 | 0.85 (0.50–1.46) | 0.561 |
| T4 | 0.92 (0.86–0.97) | 0.004 | 0.91 (0.83–1.00) | 0.043 | 1.18 (1.01–1.38) | 0.042 | 1.01 (0.84–1.22) | 0.932 | 1.72 (1.02–2.91) | 0.043 |
| N stage | ||||||||||
| N0 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| N1 | 1.01 (0.97–1.06) | 0.572 | 1.09 (1.02–1.16) | 0.012 | 0.98 (0.88–1.10) | 0.758 | 1.09 (0.97–1.23) | 0.155 | 1.20 (0.87–1.67) | 0.271 |
| N2 | 0.84 (0.77–0.92) | <0.001 | 0.99 (0.86–1.13) | 0.867 | 0.96 (0.75–1.24) | 0.745 | 0.93 (0.71–1.21) | 0.571 | 0.86 (0.43–1.73) | 0.676 |
| N3 | 0.86 (0.79–0.93) | <0.001 | 1.01 (0.87–1.17) | 0.944 | 1.11 (0.86–1.44) | 0.410 | 0.95 (0.72–1.24) | 0.686 | 1.32 (0.71–2.44) | 0.383 |
| Surgery | ||||||||||
| No | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| Yes | 0.51 (0.48–0.55) | <0.001 | 0.51 (0.46–0.57) | <0.001 | 0.73 (0.57–0.92) | 0.009 | 0.66 (0.50–0.87) | 0.003 | 0.48 (0.25–0.91) | 0.025 |
| Radiation | ||||||||||
| No/unknown | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| Yes | 0.91 (0.87–0.96) | 0.001 | 1.01 (0.93–1.09) | 0.845 | 0.80 (0.71–0.91) | <0.001 | 0.89 (0.79–0.99) | 0.036 | 0.67 (0.51–0.89) | 0.005 |
| Chemotherapy | ||||||||||
| No/unknown | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| Yes | 0.37 (0.36–0.39) | <0.001 | 0.37 (0.34–0.39) | <0.001 | 0.36 (0.32–0.40) | <0.001 | 0.38 (0.34–0.42) | <0.001 | 0.41 (0.31–0.55) | <0.001 |
| Number of mets | ||||||||||
| ≤1 | 1.00 (Reference) | 1.00 | – | – | – | – | – | – | – | – |
| >1 | 1.44 (1.37–1.53) | <0.001 | – | – | – | – | – | – | – | – |
| Other mets | ||||||||||
| No | – | – | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 | 1.00 (Reference) | 1.00 |
| Yes | – | – | 1.41 (1.32–1.50) | <0.001 | 1.27 (1.15–1.40) | <0.001 | 1.01 (0.91–1.12) | 0.813 | 1.34 (1.01–1.78) | 0.040 |
Met – metastases; HR – hazard ratio; CI – confidence interval; NOS – not otherwise specified; NA – not available.