Table 1.

Binding affinities to PKC δ and PKC βI for tigliane, ingenane, and bryostatin analogs and prodrugs

	PKC binding affinity, Ki
4 (parent)	0.5 nM, 1.4 nM*
6a	>2.5 µM†
6b	>2.5 µM, >2.5 µM*
6c	>2.5 µM†
6d	>2.5 µM, >0.5 µM*
6e	380 nM†
6f	>2.5 µM†
9 (parent)	1.1 nM, 0.85 nM*
7	>2.5 µM, >2.5 µM*
1 (parent)	1.1 nM, 2.2 nM*
8a	>1 µM‡
8b	>5 µM‡
8c	308 nM‡
8d	>5 µM‡
8e	>5 µM‡

K_i values are from a heterogeneous competitive binding assay against [³H]-phorbol dibutyrate.

^*Binding affinity to PKC δ and βI, respectively.

^†Binding affinity to PKC δ.

^‡Binding affinity to PKC βI.