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. 2020 Apr 29;117(20):10970–10975. doi: 10.1073/pnas.2005615117

Fig. 2.

Fig. 2.

The values of CRP, body temperature, concentration of oxygen inhalation, and oxygen saturation before and after the treatment with tocilizumab for the 21 patients with COVID-19. (A) CRP decreased significantly after the treatment with tocilizumab and returned to normal in the majority of the patients. (B) The fever returned to normal in all 21 patients after tocilizumab. (C and D) Before the treatment, 20 patients needed oxygen therapy except 1 who refused. After tocilizumab, 15 patients had lowered their oxygen intake, and the oxygen saturation remained stable. Among them, one patient did not need further oxygen therapy on the third day. Therefore, the concentration of his oxygen inhalation during D3-D5 has marked as 21%, similar as oxygen content in normal air. (B–D) *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.0001. D, day after tocilizumab; SpO2, percutaneous blood oxygen saturation.