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Temperature dependences for kinetic parameters of WT and Y68A COMT. Shown are Arrhenius plots of lnkcat vs. 1/T for (A) WT and (B) Y68A COMT and lnkcat/Km vs. 1/T for (C) WT and (D) Y68A. Whereas WT shows a single straight line at all temperatures, Y68A reveals a breakpoint in slope at ca. 15 to 20 °C. Data are summarized in SI Appendix, Tables S3 and S4, and tests of fitting are shown in SI Appendix, Fig. S3.
