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Dissociation constants (Kd) for AdoMet (reactant) and AdoHcy (product) with COMT at varying temperatures. Plots of Kd vs. temperature are shown for WT and Y68A enzymes as indicated. Data are summarized in SI Appendix, Tables S5 and S6; the data points in brackets for WT COMT are considered outliers, as described in SI Appendix, Table S6.
