Table 2.
The nonstructural proteins (NSPs) found in the polyprotein of SARS CoV-2
| # | Name | Accession | Amino acids | Proposed function |
|---|---|---|---|---|
| (i) | NSP1 | YP_009725297.1 | 180 amino acids | Induce host mRNA (leader protein) cleavage |
| (ii) | NSP2 | YP_009725298.1 | 638 amino acids | Binds to PHBs 1, 2 |
| (iii) | NSP3a | YP_009725299.1 | 1945 amino acids |
Release NSPs 1, 2, 3 (Papain like proteinase) |
| (iv) | NSP4 | YP_009725300.1 | 500 amino acids | Membrane rearrangement |
| (v) | NSP5a | YP_009725301.1 | 306 amino acids | Cleaves at 11 sites of (3C-like proteinase) NSP polyprotein |
| (vi) | NSP6 | YP_009725302.1 | 290 amino acids | Generates autophagosomes |
| (vii) | NSP7 | YP_009725303.1 | 83 amino acids | Dimerizes with NSP8 |
| (viii) | NSP8 | YP_009725304.1 | 198 amino acids | Stimulates NSP12 |
| (ix) | NSP9 | YP_009725305.1 | 113 amino acids | Binds to helicase(?) |
| (x) | NSP10 | YP_009725306.1 | 139 amino acids | Stimulates NSP16(?) |
| (xi) | NSP11 | YP_009725312.1 | 13 amino acids | Unknown |
| (xii) | NSP12a | YP_009725307.1 | 932 amino acids | Copies viral RNA (RNA polymerase) methylation (guanine) |
| (xiii) | NSP13 | YP_009725308.1 | 601 amino acids | Unwinds duplex RNA (Helicase) |
| (xiv) | NSP14 | YP_009725309.1 | 527 amino acids | 5′-cap RNA (3′ to 5′ exonuclease, guanine N7-methyltransferase) |
| (xv) | NSP15a | YP_009725310.1 | 346 amino acids | Degrade RNA to (endoRNAse/endoribonuclease) evade host defense |
| (xvi) | NSP16 | YP_009725311.1 | 298 amino acids | 5′-cap RNA (2′-O-ribose-methyltransferase—potential antiviral drug target) methylation (adenine) |
aIndicates possible targets of antiviral compounds