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Pharmaceutical product introductions. (a) The annual rate of new product introduction is indicated for over the counter (OTC; red) and ‘forgotten’ (black) medicines from 1901 to 1962 (the final year before implementation of the Kefauver-Harris provisions). (b) The cumulative number of OTC and forgotten medicines is indicated over time, revealing >1200 pharmaceutical ingredients available to physicians by 1962. Note this graph does not include the 347 GRAS compounds.
