Table 4.
Hazard ratios (95% CIs) of the association of each comorbidity with all-cause mortality risk
| Model 1 | Model 2 | Model 3a | Model 3b | Model 3c | |
|---|---|---|---|---|---|
| ADA comorbidities | |||||
| Coronary heart disease | 1.92 (1.56, 2.38) | 1.87 (1.50, 2.33) | 1.55 (1.24, 1.94) | 1.60 (1.28, 2.00) | 1.50 (1.20, 1.87) |
| Stroke | 1.09 (0.73, 1.61) | 1.07 (0.72, 1.58) | 0.99 (0.67, 1.47) | 0.97 (0.65, 1.44) | 0.96 (0.65, 1.43) |
| Heart failure | 2.54 (2.08, 3.10) | 2.48 (2.03, 3.04) | 2.08 (1.69, 2.57) | 2.03 (1.65, 2.50) | 1.94 (1.57, 2.39) |
| Arthritis | 1.11 (0.88, 1.40) | 1.14 (0.90, 1.44) | 1.09 (0.87, 1.38) | 1.03 (0.81, 1.30) | 1.01 (0.80, 1.28) |
| Cancer | 1.65 (1.35, 2.02) | 1.65 (1.35, 2.03) | 1.66 (1.35, 2.03) | 1.52 (1.24, 1.87) | 1.55 (1.26, 1.90) |
| Chronic kidney disease | 2.32 (1.89, 2.86) | 2.28 (1.84, 2.82) | 1.83 (1.47, 2.28) | 1.67 (1.34, 2.09) | 1.58 (1.26, 1.98) |
| Depression | 1.69 (1.10, 2.61) | 1.64 (1.06, 2.54) | 1.58 (1.02, 2.46) | 1.67 (1.08, 2.59) | 1.58 (1.02, 2.46) |
| Emphysema or COPD | 1.92 (1.44, 2.55) | 1.90 (1.43, 2.54) | 1.85 (1.38, 2.47) | 1.72 (1.29, 2.30) | 1.78 (1.33, 2.37) |
| Falls | 1.82 (1.22, 2.72) | 1.75 (1.17, 2.62) | 1.47 (0.98, 2.21) | 1.64 (1.09, 2.45) | 1.55 (1.03, 2.33) |
| Hypoglycemia | 2.64 (1.75, 3.97) | 2.39 (1.58, 3.61) | 2.08 (1.37, 3.15) | 2.11 (1.39, 3.20) | 1.97 (1.30, 2.98) |
| Hypertension | 1.05 (0.79, 1.38) | 1.02 (0.58, 1.80) | 1.08 (0.61, 1.90) | 1.03 (0.58, 1.81) | 1.08 (0.61, 1.90) |
| Incontinence | 1.22 (0.93, 1.61) | 1.21 (0.91, 1.59) | 1.16 (0.88, 1.53) | 1.09 (0.82, 1.44) | 1.08 (0.81, 1.42) |
| Geriatric syndromes | |||||
| Dementia | 2.82 (2.09, 3.80) | 2.81 (2.08, 3.80) | 2.47 (1.83, 3.34) | 2.71 (2.00, 3.66) | 2.61 (1.93, 3.53) |
| Frailty | 2.27 (1.77, 2.91) | 2.35 (1.83, 3.01) | 1.95 (1.52, 2.52) | 1.76 (1.36, 2.27) | 1.67 (1.29, 2.16) |
Model 1: adjusted for age, sex, and race-center. Model 2: model 1 + current smoking, systolic blood pressure, diastolic blood pressure, antihypertensive medication use, total cholesterol, HDL cholesterol, cholesterol-lowering medication use, and hemoglobin A1c. Model 3a: model 2 + log2-transformed hs-cTnI with five linear equipercentile spline knots. Model 3b: model 2 + log2-transformed hs-cTnT with five linear equipercentile spline knots. Model 3c: model 2 + log2-transformed hs-cTnI with five linear equipercentile spline knots and log2-transformed hs-cTnT with five linear equipercentile spline knots. ADA, American Diabetes Association; COPD, chronic obstructive pulmonary disease.