Figure 1.

Relationship between physiological and chronological age and trajectory shifts by elevated hs-cTns and medical comorbidities in older adults with diabetes. The relationship between chronological and physiological age may be modified by considering high hs-cTn (representing pathological myocardial aging) and high medical comorbidity burden. The presence of one or both entities can shift the trajectory of “normal” chronological age toward “premature aging” such that adverse outcomes are more likely to occur at a lower chronological age. Conversely, individuals with low hs-cTn and/or no significant medical comorbidity can be downgraded in mortality risk consistent with a more “healthy aging” trajectory.