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. 2020 May 17;8(1):e001178. doi: 10.1136/bmjdrc-2020-001178

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Scheme putting the study findings into context. In the presence of acute hyperglycemia, volume expansion per se can increase glucose and sodium excretion (blue dotted line). The effect of added hyperinsulinemia is to inhibit SGLT-mediated glucose and sodium reabsorption (red dotted line). Also indicated are the stimulatory action of insulin on the sodium-hydrogen cotransporter (NHE3) and a possible inhibitory action of prolonged insulin exposure on the Na+K+ pump. See text for further explanation. GLUT, glucose transporter; SGLT, sodium-glucose cotransporters.