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. 2020 May 19;13:4411–4421. doi: 10.2147/OTT.S249752

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© 2020 Liao et al.

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Analysis of Nrf2 signaling pathway. (A) A heatmap indicating the relationship between relevant pathways and corresponding DEGs. (B) Detection of expression levels of Nrf2 in PC3 cell lines transfected with si-PANX2 or si-NC using qRT-PCR. (C) Western blotting image analysis indicating reduction in expression levels of Nrf2 and its downstream members (HO-1 and FTH1) after silencing PANX2. (D, E) Selection of optimal concentrations of oltipraz. (^##p<0.01; **p<0.01).