Table 1.
Patient and tumor characteristics at baseline for all eligible patients.
Bevacizumab + Placebo (n=58) | Bevacizumab + Trebananib (n=57) | |||
---|---|---|---|---|
Patient or Tumor Characteristic | n | % | n | % |
Age (years) | ||||
Median | 58 | 57 | ||
Min - Max | 22 - 79 | 30 - 80 | ||
< 50 | 17 | 29.3 | 14 | 24.6 |
≥50 | 41 | 70.7 | 43 | 75.4 |
Gender | ||||
Male | 36 | 62.1 | 32 | 56.1 |
Female | 22 | 37.9 | 25 | 43.9 |
Race | ||||
Asian | 2 | 3.4 | 0 | 0.0 |
Black or African American | 3 | 5.2 | 2 | 3.5 |
White | 53 | 91.4 | 53 | 93.0 |
Unknown or not reported | 0 | 0.0 | 2 | 3.5 |
Ethnicity | ||||
Hispanic or Latino | 3 | 5.2 | 2 | 3.5 |
Not Hispanic or Latino | 55 | 94.8 | 54 | 94.7 |
Unknown | 0 | 0.0 | 1 | 1.8 |
Karnofsky Performance Status | ||||
70-80 | 31 | 53.4 | 34 | 59.6 |
90-100 | 27 | 46.6 | 23 | 40.4 |
Neurologic Function | ||||
No symptoms | 12 | 20.7 | 11 | 19.3 |
Minor symptoms | 32 | 55.2 | 27 | 47.4 |
Moderate symptoms (fully active) | 10 | 17.2 | 16 | 28.1 |
Moderate symptoms (required assistance) | 4 | 6.9 | 3 | 5.3 |
Surgery (Initial Brain Tumor) | ||||
Biopsy only | 8 | 13.8 | 3 | 5.3 |
Subtotal resection | 19 | 32.8 | 12 | 21.1 |
Gross total resection | 30 | 51.7 | 42 | 73.7 |
Other | 1 | 1.7 | 0 | 0.0 |
Recent resection | ||||
No/biopsy only | 30 | 51.7 | 30 | 52.6 |
Yes | 28 | 48.3 | 27 | 47.4 |
Histologic Tumor Type | ||||
Glioblastoma | 53 | 91.4 | 53 | 93.0 |
Gliosarcoma | 2 | 3.4 | 2 | 3.5 |
Glioblastoma with Oligodendroglial Features | 2 | 3.4 | 1 | 1.8 |
Giant Cell Glioblastoma | 0 | 0.0 | 1 | 1.8 |
Other | 1 | 1.7 | 0 | 0.0 |