Table 1.
Patient and tumor characteristics at baseline for all eligible patients.
| Bevacizumab + Placebo (n=58) | Bevacizumab + Trebananib (n=57) | |||
|---|---|---|---|---|
| Patient or Tumor Characteristic | n | % | n | % |
| Age (years) | ||||
| Median | 58 | 57 | ||
| Min - Max | 22 - 79 | 30 - 80 | ||
| < 50 | 17 | 29.3 | 14 | 24.6 |
| ≥50 | 41 | 70.7 | 43 | 75.4 |
| Gender | ||||
| Male | 36 | 62.1 | 32 | 56.1 |
| Female | 22 | 37.9 | 25 | 43.9 |
| Race | ||||
| Asian | 2 | 3.4 | 0 | 0.0 |
| Black or African American | 3 | 5.2 | 2 | 3.5 |
| White | 53 | 91.4 | 53 | 93.0 |
| Unknown or not reported | 0 | 0.0 | 2 | 3.5 |
| Ethnicity | ||||
| Hispanic or Latino | 3 | 5.2 | 2 | 3.5 |
| Not Hispanic or Latino | 55 | 94.8 | 54 | 94.7 |
| Unknown | 0 | 0.0 | 1 | 1.8 |
| Karnofsky Performance Status | ||||
| 70-80 | 31 | 53.4 | 34 | 59.6 |
| 90-100 | 27 | 46.6 | 23 | 40.4 |
| Neurologic Function | ||||
| No symptoms | 12 | 20.7 | 11 | 19.3 |
| Minor symptoms | 32 | 55.2 | 27 | 47.4 |
| Moderate symptoms (fully active) | 10 | 17.2 | 16 | 28.1 |
| Moderate symptoms (required assistance) | 4 | 6.9 | 3 | 5.3 |
| Surgery (Initial Brain Tumor) | ||||
| Biopsy only | 8 | 13.8 | 3 | 5.3 |
| Subtotal resection | 19 | 32.8 | 12 | 21.1 |
| Gross total resection | 30 | 51.7 | 42 | 73.7 |
| Other | 1 | 1.7 | 0 | 0.0 |
| Recent resection | ||||
| No/biopsy only | 30 | 51.7 | 30 | 52.6 |
| Yes | 28 | 48.3 | 27 | 47.4 |
| Histologic Tumor Type | ||||
| Glioblastoma | 53 | 91.4 | 53 | 93.0 |
| Gliosarcoma | 2 | 3.4 | 2 | 3.5 |
| Glioblastoma with Oligodendroglial Features | 2 | 3.4 | 1 | 1.8 |
| Giant Cell Glioblastoma | 0 | 0.0 | 1 | 1.8 |
| Other | 1 | 1.7 | 0 | 0.0 |