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. Author manuscript; available in PMC: 2021 Apr 17.
Published in final edited form as: J Mol Biol. 2020 Feb 21;432(9):2973–2984. doi: 10.1016/j.jmb.2020.02.011

Table 2:

Major opportunity areas for structural footprinting.

■ Protein complexes/ligand interactions not amenable to crystallography or Cryo-EM
■ Membrane proteins in native like states
■ Intrinsically disordered proteins
■ Amyloidogenic proteins
■ Structural kinetics and intermediates of protein machines
■ Structure of molecules in cells/tissue