Table 3:
Association between sCD14 and HF subtypes
| Models | n | HR (95% CI) per doubling of biomarker, P value | |
|---|---|---|---|
| HF with preserved EF | HF with reduced EF | ||
| sCD14 | |||
| Model 1 | 5217 | 1.70 (1.27–2.26), P<0.001 | 1.51 (1.07–2.11), P=0.018 |
| Model 2 | 4413 | 1.50 (1.07–2.10), P=0.019 | 0.99 (0.67–1.49), P=0.978 |
| Model 3 | 4142 | 1.37 (0.96–1.97), P=0.084 | 0.76 (0.50–1.17), P=0.215 |
| IL-6 | |||
| Model 1 | 4909 | 1.27 (1.16–1.40), P<0.001 | 1.35 (1.21–1.51), P<0.001 |
| Model 2 | 4151 | 1.13 (1.01–1.27), P=0.038 | 1.18 (1.02–1.36), P=0.022 |
| Model 3 | 4142 | 1.05 (0.92–1.19), P=0. 500 | 1.07 (0.90–1.25), P=0.451 |
| hsCRP | |||
| Model 1 | 5192 | 1.15 (1.08–1.21), P<0.001 | 1.26 (1.18–1.35), P<0.001 |
| Model 2 | 4399 | 1.09 (1.02–1.17), P=0.014 | 1.16 (1.07–1.26), P<0.001 |
| Model 3 | 4142 | 1.05 (0.96–1.13), P=0.285 | 1.16 (1.04–1.28), P=0.006 |
| WBC | |||
| Model 1 | 5187 | 1.78 (1.45–2.18), p<0.001 | 2.15 (1.72–2.70), P<0.001 |
| Model 2 | 4397 | 1.37 (1.08–1.75), P=0.010 | 1.38 (1.05–1.82), P=0.023 |
| Model 3 | 4142 | 1.27 (0.98–1.64), P=0.069 | 1.21 (0.89–1.64), P=0.234 |
CI = Confidence interval; EF = Ejection fraction; HF = Heart failure; HR = Hazard ratio. Model 1. Adjusted for age, sex, and race.
Model 2. Adjusted for covariates in Model 1 plus education, BMI, smoking, alcohol, physical activity score, systolic blood pressure, antihypertensive use, diabetes, estrogen use, LDL, HDL, eGFR, prevalent coronary heart disease, prevalent stroke, prevalent TIA, prevalent atrial fibrillation.
Model 3. Adjusted for covariates in Model 2 plus all other inflammatory biomarkers.