Table 3.
Risk factors for late-occurrence pain and pain interference outcomes in adult survivors.
| Late-occurrence pain | Pain interference | |||
|---|---|---|---|---|
| Moderatea | Severe/very severea | Moderateb | Quite a bit/extremeb | |
| RR(95%CI) | RR(95%CI) | RR(95%CI) | RR(95%CI) | |
| Age at diagnosis (per year) | 1.02(1.02–1.02) | 1.01(1.01–1.02) | 1.02(1.02–1.03) | 1.02(1.02–1.02) |
| Years follow-up (per year) | 1.09(1.09–1.09) | 1.11(1.11–1.12) | 1.10(1.10–1.10) | 1.12(1.11–1.12) |
| Female | 1.32(1.31–1.33) | 1.50(1.49–1.51) | 1.37(1.36–1.38) | 1.51(1.49–1.53) |
| Other than Non-Hispanic White | 1.00(0.99–1.01) | 1.17(1.15–1.18) | 1.12(1.11–1.14) | 1.37(1.34–1.39) |
| Amputation | 1.37(1.35–1.38) | 1.86(1.82–1.90) | 1.14(1.13–1.16) | 1.42(1.39–1.46) |
| Cranial radiation therapy (per 10Gy increase) | 1.02(1.01–1.02) | 1.00(0.99–1.01) | 1.02(1.01–1.02) | 1.02(1.00–1.03) |
| Total platinum score | 1.06(1.05–1.07) | 1.02(1.01–1.03) | 1.12(1.11–1.13) | 1.17(1.16–1.19) |
| Depression (per 0.5 SD) | 1.09(1.08–1.10) | 1.17(1.15–1.18) | 1.13(1.11–1.15) | 1.20(1.19–1.22) |
| Anxiety (per 0.5 SD) | 1.16(1.15–1.17) | 1.22(1.19–1.25) | 1.17(1.15–1.18) | 1.22(1.20–1.23) |
| Antidepressant use | 1.70(1.68–1.73) | 2.39(2.34–2.45) | 1.79(1.77–1.84) | 2.44(2.39–2.49) |
| Analgesic use | 3.09(3.06–3.13) | 8.00(7.88–8.17) | 3.48(3.45–3.54) | 7.25(7.13–7.39) |
| Model 2: Cancer diagnosis | RR(95%CI) | RR(95%CI) | RR(95%CI) | RR(95%CI) |
| CNS tumor | 1.06(1.04–1.07) | 1.02(1.00–1.04) | 1.03(1.01–1.04) | 1.10(1.08–1.12) |
| Lymphoma | 0.79(0.79–0.80) | 0.86(0.85–0.87) | 0.85(0.84–0.86) | 0.99(0.98–1.01) |
| Sarcoma/Bone tumor | 1.10(1.09–1.11) | 1.47(1.45–1.49) | 1.15(1.14–1.17) | 1.38(1.35–1.41) |
| Wilms’/Neuroblastoma | 0.89(0.88–0.89) | 0.96(0.95–0.97) | 0.91(0.90–0.92) | 0.74(0.73–0.76) |
| Leukemia | 1.0 | 1.0 | 1.0 | 1.0 |
| Model 3: Chronic medical condition | RR(95%CI) | RR(95%CI) | RR(95%CI) | RR(95%CI) |
| Grade 3–4 | 1.33(1.32–1.34) | 1.76(1.75–1.78) | 1.39(1.38–1.40) | 2.06(2.04–2.07) |
| Grade 0–2 | 1.0 | 1.0 | 1.0 | 1.0 |
Notes. RR(95% CI) bolded to indicate p<0.05.
a
Reference group is none to mild late-occurrence pain.
b
Reference group is not at all to a little bit of pain interference.