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. Author manuscript; available in PMC: 2021 May 21.
Published in final edited form as: Cell Chem Biol. 2020 Mar 19;27(5):560–570.e10. doi: 10.1016/j.chembiol.2020.02.007

Figure 1. Depiction of the Transposition Hypothesis from DG167 to Indoles or Indazoles, Eventually Leading to JSF-3285.

Figure 1.

The transposition to either heterocycle would maintain the key interactions of the alkyl sulfonamide moiety and the hydrophobic contacts of the DG167 1-methyl moiety while obviating the metabolic lability of the 1-methyl and introducing hydrogen bonding interactions with Glu120. A 2-substituent has the potential of engaging Glu203. This strategy ultimately led to JSF-3285.