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. Author manuscript; available in PMC: 2021 May 21.
Published in final edited form as: Cell Chem Biol. 2020 Mar 19;27(5):560–570.e10. doi: 10.1016/j.chembiol.2020.02.007

Table 1.

Key Properties of Select Transposed Indoles

graphic file with name nihms-1572786-t0007.jpg
Compound R1 R2 MIC H37Rv (μM) Vero CC50 (μM) MLM t1/2 (min) Kinetic Aqueous Solubility (μM)
DG167a 0.39 23 10.1 324
4 H NHSO2-n-Bu 1.6 >190 nd nd
5 CO2Et NHSO2-n-Bu 0.20 >150 <0.5 0.895
8 CONH2 NHSO2-n-Bu 3.1 >160 6.16 45.5
9 CN NHSO2-n-Bu 0.78 170 6.51 133
10 CN NHSO2-n-Pen 0.20 160 4.08 7.21
11 CH2NH2 NHSO2-n-Bu 100 170 nd nd

nd, not determined.

a

Kumar et al. (2018) reference.