Table 2.
Pharmacokinetic Parameter Estimates for UDCA Obtained Using Noncompartmental Analysis
| Subject ID | Dose (mg/ kg) | tmax (h) | Cmax (ng/mL) | Cmin (ng/mL) | AUC(0-tau) (μg • h/mL) | Clss/F (mL/min/kg) | Vz/F (mL/kg) | Half-life (t1/2) (h) | Accum. index | Fluctuation % |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 30 | 2.5 | 5441 | 613 | 21.0 | 9.0 | 1556 | 2.0 | 1.07 | 184 |
| 2 | 50 | 1 | 10 377 | 2603 | 38.4 | 7.7 | 1438 | 2.1 | 1.08 | 162 |
| 3 | 50 | 1 | 5166 | 902 | 19.5 | 16.6 | 4445 | 3.1 | 1.20 | 175 |
| 4 | 50 | 2 | 11 523 | 780 | 28.0 | 10.2 | 845 | 1.0 | 1.00 | 307 |
| 5 | 50 | 2.9 | 11 237 | 934 | 23.5 | 15.2 | 1466 | 1.1 | 1.01 | 351 |
| Mean | … | 1.9 | 8749 | 1166 | 27.4 | 11.8 | 1950 | 1.9 | 1.1 | 236 |
| Standard deviation | … | 0.8 | 2840 | 727 | 7.1 | 3.5 | 1273 | 0.8 | 0.1 | 77.6 |
AUC(0-tau), area under the concentration-time curve from time 0 to infinity, CLss/F, apparent clearance at steady state, Cmax, maximum plasma concentration; Cmin, minimum plasma concentration; Tmax, time at maximum concentration; Vz/F, apparent volume of distribution.