Table 1.
Compound Information about Select Pharmacological Chaperones of ecDHFR DDs with Diverse Functions
| Compound | Structure | AC50 (nM) | Primary Target | Reference |
|---|---|---|---|---|
| TMP |  |
19–52 | Escherichia coli DHFR | Reisberg et al., 1966 |
| Pralatrexate |  |
110 | Homo sapiens DHFR | DeGraw et al., 1993 |
| GW2580 |  |
240 | cFMS kinase | Conway et al., 2005 |
| TG100-115 |  |
2,500 | PI3Kγ/δ | Doukas et al., 2006 |
| TC-P 262 |  |
3,400 | P2X3 and P2X2/3 | Ballini et al., 2011 |
| Pyrimethamine |  |
7,200 | protozoal DHFR | Jaswant et al., 1951 |
| Triamterene |  |
>10,000 | ENaC | Crosley et al., 1962 |
| 7,8-DQ-2,4-DA |  |
>10,000 | GCase PC | Tropak et al., 2008 |
| 2,4-DAQ |  |
>10,000 | uncertain | N/A |
| HZ-1157 |  |
>10,000 | HCV NS3/4A protease | Yu et al., 2014 |