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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Obesity (Silver Spring). 2020 Apr 29;28(6):1075–1085. doi: 10.1002/oby.22763

Figure 2.

Figure 2.

Weight loss in male obese mice occurs following a switch to MR in the absence of ADIPOQ and FGF21. (A - C) Body weights and (D - F) daily food consumption of Adipoq-KO DIO-CF, Fgf21-KO DIO-CF, and AF-dKO DIO-CF (open circles) and -MR mice (filled circles). (G - I) The ratios of perigonadal (pgWAT), inguinal (iWAT), and intrascapular BAT masses relative to body weight in Adipoq-KO DIO-CF, Fgf21-KO DIO-CF, and AF-dKO DIO-CF (white bars) and -MR (black bars) mice. (J) H & E staining of iWAT from Adipoq-KO (left panels), Fgf21-KO (middle panels), and AF-dKO (right panels) DIO-CF (Top panels) and -MR (Bottom panels) mice. Scale bar denotes 100µm. Statistical analysis was conducted using 2-way ANOVA for time-course experiments (A - F) or Student’s t-test between CF and MR for each adipose tissue depot (G - I), as described in Methods (n = 7 – 8 / group, ***P < 0.001, *P < 0.05).