Table 1.

Body and adipose tissue masses of male WT DIO mice and mice lacking in adiponectin (Adipoq-KO), FGF21 (Fgf21-KO), or both (AF-dKO) fed a high fat (DIO) CF or MR diet. Comparisons between CF and MR in each cohort were conducted using Student’s unpaired t-test (n = 5 – 8 / group, ***P < 0.001, **P < 0.01).

Mass (ga)	WT DIO		Adipoq-KO DIO		Fgf21-KO DIO		AF-dKO DIO
	CF	MR	CF	MR	CF	MR	CF	MR
Initial Body Weight	42.9 ± 2.9	43.6 ± 3.1	35.4 ± 6.4	32.7 ± 6.9	30.8 ± 2.3	33.3 ± 2.3	30.6 ± 3.7	30.4 ± 3.2
Final Body Weight	46.6 ± 3.3	24.1 ± 1.0***	39.2 ± 7.7	20.6 ± 1.3***	31.7 ± 3.3	19.8 ± 0.5***	32.9 ± 5.5	19.4 ± 1.1***
Body Weight Change	3.6 ± 2.4	−19.6 ± 2.5***	3.4 ± 3.5	−12.1 ± 3.5***	0.9 ± 1.4	−13.5 ± 2.4***	2.4 ± 2.3	−10.3 ± 2.4***
pgWAT	2.4 ± 0.3	0.42 ± 0.04	1.9 ± 0.4	0.51 ± 0.08	2.0 ± 0.5	0.17 ± 0.06	1.6 ± 0.6	0.34 ± 0.08**
iWAT	2.0 ± 0.5	0.31 ± 0.03***	1.2 ± 0.5	0.25 ± 0.05***	0.6 ± 0.3	0.10 ± 0.02***	0.73 ± 0.3	0.13 ± 0.01**
BAT	0.48 ± 0.1	0.11 ± 0.02***	0.42 ± 0.2	0.10 ± 0.01***	0.20 ± 0.05	0.08 ± 0.02***	0.23 ± 0.06	0.06 ± 0.01***

^aValues are mean ± SD.