Confusion has arisen over whether use of NSAIDs may increase the likelihood of contracting COVID-19 and/or if NSAIDs may exacerbate symptoms in people with COVID-19.

Hyperactive inflammatory response called “cytokine storm” can occur with COVID-19 and plays a major role in negative outcomes, but the role of anti-inflammatories, such as (but not limited to) NSAIDs, is unclear.

To date, there is no strong evidence pro or con for the use of NSAIDs in a person diagnosed with COVID-19.

Oral NSAIDs used briefly during a mild episode of COVID-19 are not necessarily comparable to round-the-clock parenteral NSAID administration in a critical patient.

Acetaminophen (paracetamol) may be administered to patients with COVID-19 but caution must be observed with dosing.