Table 3.
Univariate and multivariate Cox regression analyses of locoregional recurrences
| Univariate analysis | Multivariate model | ||||||
|---|---|---|---|---|---|---|---|
| n | 5-year rate | 95%CI | p** | Hazard ratio | 95% CI | p | |
| All | 2158 | 5.6 | 4.6–6.6 | ||||
| Age (years) | |||||||
| < 65 | 1079 | 5.7 | 4.3–7.1 | ||||
| ≥ 65 | 1079 | 5.6 | 4.2–7.0 | 0.718 | |||
| Sex | |||||||
| Male | 1351 | 6.5 | 5.1–7.9 | 1.0 | |||
| Female | 807 | 4.1 | 2.7–5.5 | 0.010 | 0.7 | 0.4–1.0 | 0.050 |
| ASA* | |||||||
| ASA I–II | 1498 | 4.8 | 3.6–6.0 | ||||
| ASA III–IV | 336 | 6.4 | 3.5–9.3 | 0.344 | |||
| Tumour site | |||||||
| Colon | 990 | 2.2 | 1.2–3.2 | 1.0 | |||
| Rectum | 1168 | 8.5 | 6.7–10.3 | < 0.001 | 5.3 | 3.2–8.8 | < 0.001 |
| Stage (UICC) | |||||||
| Stage I | 573 | 3.5 | 1.9–5.1 | 1.0 | |||
| Stage II | 535 | 4.6 | 2.8–6.4 | 2.2 | 1.3–4.0 | 0.006 | |
| Stage III | 500 | 7.7 | 5.2–10.2 | 2.7 | 1.5–4.6 | < 0.001 | |
| Stage y0 | 73 | 0 | 0 | 0.954 | |||
| Stage yI | 164 | 4.5 | 1.2–7.8 | 0.6 | 0.3–1.5 | 0.296 | |
| Stage yII | 146 | 9.6 | 4.5–14.7 | 1.7 | 0.9–3.3 | 0.118 | |
| Stage yIII | 167 | 10.2 | 5.3–15.1 | < 0.001 | 1.9 | 1.0–3.5 | 0.061 |
| Clavien-Dindo classification | |||||||
| 0 | 1691 | 5.3 | 4.1–6.5 | 1.0 | |||
| I | 141 | 4.4 | 0.7–8.1 | 0.9 | 0.4–1.8 | 0.683 | |
| II | 162 | 4.8 | 1.3–8.3 | 1.0 | 0.5–1.9 | 0.948 | |
| III | 112 | 12.9 | 6.2–19.6 | 2.2 | 1.3–3.9 | 0.005 | |
| IV | 52 | 4.3 | 0–10.2 | 0.007 | 0.8 | 0.2–3.1 | 0.699 |
ASA American Society of Anesthesiologists Classification; *ASA missing in 324 patients
**Log-rank test