Table 6.

Univariate and multivariate Cox regression analyses of overall survival

		Univariate analysis			Multivariate model adjusted for age
	n	5-year rate	95% CI	p**	Hazard ratio	95% CI	p
All	2158	81.3	79.7–82.9
Age (years
< 65	1079	88.3	86.3–90.3
≥ 65	1079	74.4	71.9–76.9	< 0.001
Sex
Male	1351	80.2	78.0–82.4		1.0
Female	807	83.2	80.7–85.7	0.001	0.8	0.7–0.9	0.002
ASA*
ASA I-II	1498	85.2	83.4–87.0	85.2	1.0
ASA III-IV	336	63.6	58.3–68.9	63.6	1.9	1.6–2.3	< 0.001
Tumour site
Colon	990	82.5	80.1–84.9
Rectum	1168	80.3	77.9–82.7	0.306
Stage (UICC)
Stage I	573	88.2	85.5–90.9		1.0
Stage II	535	81.7	78.4–85.0		1.2	1.0–1.5	0.120
Stage III	500	70.9	66.8–75.0		1.7	1.3–2.0	< 0.001
Stage y0	73	98.6	95.9–100		0.7	0.4–1.3	0.290
Stage yI	164	94.4	90.9–97.9		0.9	0.6–1.3	0.504
Stage yII	146	74.6	67.3–81.9		1.8	1.3–2.4	< 0.001
Stage yIII	167	73.5	66.8–80.2	< 0.001	2.3	1.7–3.0	< 0.001
Clavien-Dindo classification
0	1691	83.5	81.7–85.3		1.0
I	141	76.2	69.1–93.3		1.6	1.2–2.1	< 0.001
II	162	72.7	65.8–79.6		1.5	1.2–1.9	0.001
III	112	76.5	68.7–84.3		1.4	1.1–2.0	0.022
IV	52	63.1	50.0–76.2	< 0.001	1.9	1.3–2.7	0.001

ASA American Society of Anesthesiologists Classification; *ASA missing in 324 patients

**Log-rank test