. Author manuscript; available in PMC: 2020 May 24.

Published in final edited form as: Heart Fail Rev. 2013 Jan;18(1):79–94. doi: 10.1007/s10741-012-9332-0

Table 7.

Results of sub-study meta-analyses

	# Studies	DOR (95 % CI)	I-squared	Cochran-Q/p value	Tau-squared

Sub-study
Peak VO₂ threshold
Peak VO₂ < 14 ml kg⁻¹ min⁻¹	4	5.58 (2.39–13.02)	81.8	16.47/0.0009	0.569
Peak VO₂ = 14 ml kg⁻¹ min⁻¹	10	3.43 (2.48–4.74)	67.5	27.73/0.001	0.162
Peak VO₂ > 14 ml kg⁻¹ min⁻¹	5	5.34 (3.15–9.04)	66.1	11.80/0.02	0.222
VE/VCO₂ slope threshold
VE/VCO₂ = 34	6	4.53 (3.13–6.54)	43.5	8.85/0.12	0.085
VE/VCO₂ > 34 < 40	10	6.22 (4.10–9.43)	63.9	24.95/0.003	0.244
VE/VCO₂ > 40	5	4.83 (3.68–6.35)	0	1.26/0.86	0
Peak VO₂ with and without beta-blockade
Peak VO₂ without beta-blockade	7	4.48 (2.95–6.80)	66.7	17.99/0.006	0.195
Peak VO₂ with beta-blockade	12	3.90 (2.76–5.52)	73.4	41.37/0.0000	0.239
VE/VCO₂ slope with and without beta-blockade
VE/VCO₂ without beta-blockade	5	5.25 (3.82–7.23)	0	3.72/0.44	0
VE/VCO₂ with beta-blockade	10	5.44 (3.79–7.79)	59.6	22.26/0.008	0.169
Peak VO₂ and left ventricular ejection fraction
Peak VO₂ with LVEF < 25 %	6	3.41 (2.02–5.75)	74.6	19.66/0.001	0.281
Peak VO₂ with LVEF > 25 % < 30 %	7	5.79 (3.73–8.99)	57.2	14.03/0.03	0.183
Peak VO₂ with LVEF > 30 %	4	4.41 (2.39–8.15)	76.4	12.71/0.005	0.274
VE/VCO₂ slope and ejection fraction
VE/VCO₂ with LVEF < 30 %	8	5.37 (4.24–6.81)	0	5.34/0.62	0
VE/VCO₂ with LVEF > 30 %	6	5.59 (3.16–9.87)	73.7	19.00/0.002	0.328