Table 3.
Clinic trails of stem cell therapy on influenza virus and CoVs induced lung injury
| ID | Cell sources | Virus type | Enrollment | Intervetion | Follow-up | Status | Results | Country |
|---|---|---|---|---|---|---|---|---|
| ChiCTR-OCC-15006355 | Menstrual blood derived MSCs | H7N9 avian influenza | 61 (44/17) | I million cells/kg three times, i.v. | 5 years | Completed | MSCs transplantation significantly lowered the mortality | China |
| NCT02095444 | Menstrual blood stem cells | H7N9 avian influenza | 20 | 107 cells/kg, i.v. 4 times in 2 weeks | 2.5 years | Unknown | No results posted | China |
| ChiCTR2000030835 | hUC-MSCs | SARS-CoV-2 | 20 | 2 or 1 million cells/kg, three times, i.v. | 1 year | Recruiting | No results posted | China |
| ChiCTR2000029990 | MSCs | SARS-CoV-2 | 120 (60/60) | No details | 14 months | Recruiting | No results posted | China |
| NCT04333368 | hUC-MSCs | SARS-CoV-2 | 60 | I million cells/kg, three times, i.v. | 14 months | Not yet recruiting | No results posted | France |
| NCT04313322 | WJ-MSCs | SARS-CoV-2 | 5 | No details | 6 months | Recruiting | No results posted | Jordan |
| NCT04336254 | hDP-MSCs | SARS-CoV-2 | 20 | 107 cells/kg, i.v. 3 times in 1 week | 1 year | Recruiting | No results posted | China |
All information was extracted from http://www.chictr.org.cn/ and https://www.clinicaltrials.gov/
MSCs mesenchymal stem/stromal cells, WJ Wharton’s jelly, i.v. intravenous, DP dental pulp, UC umbilical cord