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Biochemical assays. Liver tissues homogenates from control and SORA groups were obtained to analyze catalase activity (a), NAD+/NADH ratio (b), GSH (c), and GSSG (d). Data are presented as mean ± SD. Comparison between the control group and the sorafenib group is presented by ∗, where ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. SORA: sorafenib; NAD: Nicotinamide adenine dinucleotide; GSH: glutathione; GSSG: oxidized glutathione.
