Fig. 1.

High fat diet changed lipid profiles in serum and liver tissues at week 38. a High fat diet significantly increased the serum total cholesterol (TC), low density lipoprotein cholesterol (LDL), blood glucose (Glu), and body weight (BW) levels of mice at both week 16 and 38. b High fat diet significantly increased the serum AST and ALT levels of mice at week 38. c Liver histopathology (HE, × 40) showing the fat accumulation in hepatocytes of mice treated by high fat diet for 38 weeks. Abbreviation: ND, normal diet group; HFD, high fat diet group. Data were presented as mean ± SEM. ^*p < 0.05 checked by the two-way ANOVA forllowed by the Tukey’s test