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. 2020 May 24;39:92. doi: 10.1186/s13046-020-01587-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Association of TP53INP1 expression with MSI2 expression. a Immunohistochemistry. TNBC tissues were subjected to immunohistochemical staining of MSI2 and TP53INP1. Representative images were acquired with 10× and 20× objectives. Scale bar, 100 μm and 200 μm. b Plot depicting the positive correlation between MSI2 protein expression and TP53INP1 protein expression in TNBC. c Kaplan-Meier survival curves comparing OS of breast cancer combined with MSI2 mRNA and TP53INP1 mRNA expression. d Kaplan-Meier survival curves comparing OS of breast cancer combined with MSI2 mRNA and TP53INP1 mRNA expression. e A schematic model of MSI2/TP53INP1 function during TNBC metastasis. Normally, MSI2a interacts with the 3’UTR of TP53INP1 mRNA, leading to the stabilization of TP53INP1 mRNA, which in turn ensures complete p-ERK inactivation. In the case of MSI2a dysregulation in TNBC, TP53INP1 mRNA becomes unstable, resulting in decreased TP53INP1, inevitably causing increased p-ERK and TNBC metastasis