Table 3.
The univariables and multi-variables cox regression of clinical parameters and survival outcomes of patients with osteosarcoma
| Clinical characteristics | TCGA(N = 176) | Uni-variables cox | Multi-variables cox | ||||
|---|---|---|---|---|---|---|---|
| HR | 95%CI | P | HR | 95%CI | P | ||
| Age(years, mean ± sd) | 61.01 ± 15.23 | 1.018 | 0.999–1.036 | 5.19E-02 | – | – | – |
| Gender(Male/Female) | 72/104 | 1.102 | 0.666–1.827 | 7.05E-01 | – | – | – |
| Pathologic tumor depth(years, mean ± sd) | 6.35 ± 3.69 | 1.136 | 0.951–1.227 | 9.05E-02 | – | – | – |
| Pathologic tumor length(years, mean ± sd) | 11.76 ± 7.25 | 1.061 | 0.993–1.092 | 5.91E-02 | – | – | – |
| Pathologic tumor width(years, mean ± sd) | 8.78 ± 5.51 | 1.091 | 0.940–1.143 | 2.17E-01 | – | – | – |
| Tumor multifocal(Yes/No/−) | 34/132/10 | 1.685 | 0.949–2.991 | 7.13E-02 | – | – | – |
| Tumor recurrence(Yes/No/−) | 28/141/7 | 2.692 | 1.581–4.585 | 1.48E-04 | 1.626 | 0.914–2.893 | 9.80E-02 |
| Tumor metastatic(Yes/No/−) | 58/118 | 2.898 | 1.754–4.789 | 1.36E-05 | 1.879 | 1.079–3.274 | 2.58E-02 |
| Radiotherapy(Yes/No/−) | 64/110/2 | 0.799 | 0.474–1.347 | 3.99E-01 | – | – | – |
| Tumor necrosis(No/Slight/Moderate/Severe/−) | 61/35/59/10/11 | 1.191 | 0.925–1.530 | 1.75E-01 | – | – | – |
| RS model status(High/ Low) | 88/88 | 3.13 | 1.824–5.370 | 1.28E-05 | 2.288 | 1.291–4.057 | 4.60E-03 |
| Dead(Death/Alive/−) | 63/113 | – | – | – | – | – | – |
| Overall survival time(months, mean ± sd) | 39.76 ± 32.24 | – | – | – | – | – | – |
SD Standard deviation, HR Hazard ratio, 95%CI 95% confidence interval, TCGAThe Cancer Genome Atlas