Table 4.

Ten most frequent drug-reaction pairs according to age group

Generic name	Reaction	n (%)
a. < 10 years
Oseltamivir	Abnormal behavior	257 (0.8)
Rurioctocog alfa pegol (Genetical recombination)	Factor VIII inhibition	102 (0.3)
Zanamivir	Abnormal behavior	82 (0.3)
Cyclosporine	Posterior reversible encephalopathy syndrome	71 (0.2)
Theophylline	Seizure	53 (0.2)
Acetaminophen	Toxic epidermal necrolysis	52 (0.2)
Theophylline	Encephalopathy	50 (0.2)
Oseltamivir	Seizure	48 (0.2)
Acetaminophen	Stevens-Johnson syndrome	44 (0.1)
Amoxicillin	Erythema multiforme	44 (0.1)
b. 10–19 years
Zanamivir	Abnormal behavior	216 (0.8)
Oseltamivir	Abnormal behavior	142 (0.5)
Carbamazepine	Drug reaction with eosinophilia and systemic symptoms	59 (0.2)
Zanamivir	Hallucination	59 (0.2)
L-Asparaginase	Pancreatitis acute	46 (0.2)
Cyclosporine	Nephropathy toxic	42 (0.2)
Irradiated platelet concentrate, leukocytes reduced	Anaphylactic reaction	38 (0.1)
Lamotrigine	Rash	38 (0.1)
Levetiracetam	Epilepsy	37 (0.1)
Vincristine	Neutropenia	37 (0.1)