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. 2020 May 23;27:68. doi: 10.1186/s12929-020-00660-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Effects of AT₁R antagonist on blood pressure, sympathetic vasomotor activity, ROS level and expressions of AT₁R, gp91phox or SOD2 protein in RVLM of young offspring exposed to maternal HFD or ND. a tissue ROS level; b SBP; c sympathetic vasomotor activity; and representative gels and densitometric analysis of results from Western blot showing changes in protein expression of (d) AT₁R, (e) gp91^phox, or (f) SOD2 in RVLM of ND or HFD offspring, alone or with additional treatment with an AT1R antagonist, losartan (3 μg·μL^− 1·h^− 1), microinfused via a minipump into the cistern magna at age of 8 weeks for 4 weeks. Analysis was performed on tissues collected bilaterally from individual RVLM at age of 12 weeks. Data on protein expression were normalized to the average ND control value, which is set to 1.0, and are presented as mean ± SEM (n = 6 in all groups). *P < 0.05 versus ND group and ^#P < 0.05 versus HFD group in post hoc Newman-Keuls multiple-range test