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. 2020 May 23;17:162. doi: 10.1186/s12974-020-01834-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The chronic post-ischemia pain (CPIP) rat model exhibits persistent mechanical allodynia. a Representative photographs of rat hind paw taken before the CPIP model establishment, during ischemia, 3 h and 7 days after the model establishment. The red arrow indicates the O-ring clamped right above the ankle. b, c The paw swelling of ipsilateral and contralateral hind paws of CPIP and Sham group rats. d, e 50% paw withdraw threshold (PWT) of ipsilateral and contralateral hind paws of sham and CPIP group rats. **p < 0.01 vs. sham group. n = 8 rats/group. Two-way ANOVA followed by Tukey’s post hoc test was used for comparison