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. 2020 May 23;17:162. doi: 10.1186/s12974-020-01834-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Pharmacological blocking NLRP3 inflammasome activation attenuates astrocyte and microglial activation in SCDH of CPIP rats. a Representative photos of ipsilateral SCDH stained with GFAP antibody showing astrocytes from Sham+Veh, CPIP+Veh, and CPIP+MCC950 group. Scale bar = 100 μm. b Summary of the normalized fluorescence intensity (%) of GFAP staining in ipsilateral SCDH. n = 5 rats/group. c Summary of the number of astrocytes observed in ipsilateral SCDH per observation field. n = 5 rats/group. d Representative photos of ipsilateral SCDH stained with OX42 antibody showing microglia from Sham+Veh, CPIP+Veh, and CPIP+MCC950 group. Scale bar = 100 μm. e Summary of the normalized fluorescence intensity (%) of OX42 staining in ipsilateral SCDH. n = 6 rats/group. f Summary of the number of microglia observed in ipsilateral SCDH per observation field. n = 6 rats/group. ^**p < 0.01 vs. Sham+Veh group. ^#p < 0.05, ^##p < 0.01 vs. CPIP+Veh group. One-way ANOVA followed by Tukey’s post hoc test was used for comparison