Table 2.
Cumulative cancer risks (%) by age
| LS | |||||||
|---|---|---|---|---|---|---|---|
| Cancer type | Age (years) | FCCX | LLS | LS | MLH1 | MSH2 | MSH6 |
| Any | 40 | 0.0 (−) | 12.5 (4.2–34.1) | 12.2 (6.4–22.5) | 14.0 (5.5–33.1) | 13.8 (5.7–31.4) | 0.0 (−) |
| 50 | 10.0 (1.5–52.7) | 20.5 (9.7–40.4) | 25.6 (17.5–36.4) | 24.1 (12.8–42.6) | 31.6 (19.5–48.5) | 7.7 (1.1–43.4) | |
| 60 | 10.0 (1.5–52.7) | 27.3 (14.5–47.8) | 49.0 (37.5–61.9) | 44.0 (26.6–66.3) | 60.3 (44.0–77.1) | 20.9 (5.3–63.3) | |
| 70 | 25.0 (6.6–70.2) | 27.3 (14.5–47.8) | 63.7 (48.5–78.8) | 52.0 (31.9–75.3) | 72.2 (53.2–88.4) | 36.7 (12.7–78.6) | |
| Colorectal | 40 | 0.0 (−) | 12.4 (4.2–33.8) | 8.4 (3.7–18.3) | 10.0 (3.3–27.9) | 9.5 (2.9–28.3) | 0.0 (−) |
| 50 | 0.0 (−) | 17.4 (7.5–37.4) | 11.8 (6.3–21.5) | 10.0 (3.3–27.9) | 16.3 (7.7–32.7) | 0.0 (−) | |
| 60 | 0.0 (−) | 21.0 (9.9–41.3) | 25.4 (16.8–37.2) | 23.4 (10.8–46.6) | 33.7 (21.0–51.1) | 0.0 (−) | |
| 70 | 0.0 (−) | 21.0 (9.9–41.3) | 40.9 (28.3–56.4) | 30.4 (14.8–55.8) | 49.1 (32.9–68.1) | 14.3 (2.1–66.6) | |
| Stomach | 40 | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) |
| 50 | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) | |
| 60 | 0.0 (−) | 2.4 (0.6–9.9) | 1.7 (0.6–4.6) | 0.9 (0.1–6.4) | 2.4 (0.8–7.4) | 0.0 (−) | |
| 70 | 0.0 (−) | 4.6 (1.4–14.5) | 2.9 (1.3–6.5) | 2.5 (0.6–9.9) | 3.6 (1.3–9.5) | 0.0 (−) | |
| Small bowel | 40 | 0.0 (−) | 0.0 (−) | 0.6 (0.1–4.1) | 1.4 (0.2–9.8) | 0.0 (−) | 0.0 (−) |
| 50 | 0.0 (−) | 0.6 (0.1–4.4) | 1.8 (0.7–4.8) | 1.4 (0.2–9.8) | 2.5 (0.8–7.7) | 0.0 (−) | |
| 60 | 0.0 (−) | 0.6 (0.1–4.4) | 5.9 (3.5–10.1) | 5.0 (1.9–12.8) | 7.6 (4.0–14.2) | 0.0 (−) | |
| 70 | 0.0 (−) | 0.6 (0.1–4.4) | 11.7 (7.6–17.6) | 11.5 (5.8–22.0) | 13.9 (8.0–23.4) | 0.0 (−) | |
| Urothelial | 40 | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) |
| 50 | 0.0 (−) | 0.0 (−) | 2.7 (1.3–5.6) | 0.9 (0.1–6.1) | 4.7 (2.1–10.3) | 0.0 (−) | |
| 60 | 0.0 (−) | 1.5 (0.4–5.9) | 6.5 (4.0–10.4) | 5.7 (2.4–13.3) | 8.4 (4.7–14.7) | 0.0 (−) | |
| 70 | 0.0 (−) | 5.7 (2.0–16.0) | 12.5 (8.3–18.5) | 11.3 (5.6–22.0) | 16.3 (9.9–26.2) | 0.0 (−) | |
| Female breast | 40 | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) | 0.0 (−) |
| 50 | 0.0 (−) | 2.9 (0.7–11.4) | 3.4 (1.3–8.7) | 2.0 (0.3–13.6) | 1.6 (0.2–10.6) | 12.0 (3.1–40.6) | |
| 60 | 5.9 (0.9–35.0) | 2.9 (0.7–11.4) | 7.9 (4.2–14.7) | 7.3 (2.4–21.2) | 6.8 (2.6–17.1) | 12.0 (3.1–40.6) | |
| 70 | 5.9 (0.9–35.0) | 2.9 (0.7–11.4) | 11.9 (6.8–20.3) | 7.3 (2.4–21.2) | 12.2 (5.5–25.8) | 20.8 (7.0–53.0) | |
| Ovarian | 40 | 0.0 (−) | 0.0 (−) | 1.0 (0.1–7.1) | 0.0 (−) | 2.4 (0.3–16.1) | 0.0 (−) |
| 50 | 0.0 (−) | 0.0 (−) | 2.9 (0.9–8.7) | 0.0 (−) | 6.8 (2.2–19.6) | 0.0 (−) | |
| 60 | 0.0 (−) | 0.0 (−) | 4.9 (1.7–13.3) | 0.0 (−) | 10.7 (4.0–26.9) | 0.0 (−) | |
| 70 | 0.0 (−) | 0.0 (−) | 6.4 (2.6–15.5) | 0.0 (−) | 14.0 (5.9–31.2) | 0.0 (−) | |
| Endometrial | 40 | 0.0 (−) | 0.0 (−) | 1.4 (0.2–9.3) | 0.0 (−) | 3.1 (0.4–20.2) | 0.0 (−) |
| 50 | 0.0 (−) | 4.3 (1.4–12.8) | 15.3 (9.1–25.0) | 14.5 (6.8–29.6) | 16.8 (7.9–33.8) | 10.0 (1.5–52.7) | |
| 60 | 0.0 (−) | 7.7 (3.2–17.6) | 28.8 (19.1–41.9) | 19.2 (9.2–37.5) | 40.1 (24.5–60.7) | 10.0 (1.5–52.7) | |
| 70 | 0.0 (−) | 7.7 (3.2–17.6) | 36.1 (23.4–52.7) | 35.4 (13.8–72.2) | 44.1 (27.8–64.5) | 10.0 (1.5–52.7) | |
Numbers in brackets are 95% confidence intervals