Table 2.

Cox regression analysis of LRIG1 loss, normal, and gain adjusted for all variables in all patients

Tumor characteristic	Overall survival		Metastasis-free survival
	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Age at diagnosis
≤ 50 years	Reference
> 50 years	2.633 (1.802–3.848)	< 0.001	1.306 (0.828–2.060)	0.251
Tumor subtype
ERBB2-, ER/PR+	Reference
ERBB2+, ER/PR-	1.558 (1.003–2.420)	0.049	1.915 (1.077–3.405)	0.027
ERBB2+, ER/PR+	1.563 (0.974–2.507)	0.064	1.983 (1.101–3.573)	0.023
ERBB2-, ER/PR-	1.384 (0.939–2.038)	0.1	1.583 (0.936–2.679)	0.087
Grade
Low (1 or 2)	Reference
High (3)	1.0 (1.0–1.0)	0.710	1.583 (0.936–2.679)	0.087
Tumor size
≤ 20 mm	Reference
> 20 mm	1.427 (1.067–1.908)	0.017	1.151 (0.751–1.762)	0.519
Nodal status
Negative	Reference
Positive	2.592 (1.840–3.651)	< 0.001	3.435 (2.206–5.347)	< 0.001
LRIG1copy number
Normal	Reference
Loss	0.964 (0.668–1.393)	0.847	1.115 (0.690–1.803)	0.657
Gain	0.837 (0.550–1.274)	0.407	1.041 (0.585–1.852)	0.892