Fig. 3.

Schematic representation for the functions of MSI1 in various cancer types. Downregulation of Msi1 by binding of tumor suppressor miRNAs could inhibit the growth of tumor cells in different solid tumors. Furthermore, some small molecules like luteolin and gossypol could interact with RNA binding domain1 (RBD1) in CDS of MSI1 and prevent proliferation of cancer cells and migration. But RNA-binding protein HuR stabilizes MSI1 and promotes gliblastoma by binding to 3′UTR of MSI1