Fig. 2.

a–d Microscopic sections of the corpus callosum genu. a H&E section of destructive hemorrhagic white matter lesion. b H&E section with white matter pallor adjacent to hemorrhagic lesion with GFAP immunoreactive reactive astrocytes evenly distributed in the white matter (inset) c CD68 immunostaining highlights a collection of macrophages at the periphery of the hemorrhagic lesion and a macrophages within an area of white matter pallor. d APP immunostain identifies axonal swellings within the hemorrhagic lesion and an absence of damaged axons within adjacent region of demyelination. e, f LFB/PAS stain distinguishes the focal area of myelin loss within the hemorrhagic lesion and adjacent PAS-positive foamy macrophages tracking along blood vessels and (f) higher magnification of the perivascular macrophages